Pascal Braun
http://ccsb.dfci.harvard.edu/web/www/ccsb/publications/2011_papers.html
We recently completed mapping of the first binary interactome network for the reference plant Arabidopsis thaliana. Using tools of graph theory we identify biologically relevant network communities from which a picture of the overall interactome network organization starts to emerge. Combination of interaction and comparative genomics data yielded insights into network evolution, and biological inspection resulted in many hypotheses for unknown proteins and revealed unexpected connectivity between previously studied components of phytohormone signaling pathways.
Interactome Networks and Human Disease
http://www.cell.com/abstract/S0092-8674%2811%2900130-9
Summary
Complex biological systems and cellular networks may underlie most genotype to phenotype relationships. Here, we review basic concepts in network biology, discussing different types of interactome networks and the insights that can come from analyzing them. We elaborate on why interactome networks are important to consider in biology, how they can be mapped and integrated with each other, what global properties are starting to emerge from interactome network models, and how these properties may relate to human disease.
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