good introduction to computational approaches for population genetics
Applications of the coalescent. The coalescent has traditionally been used in severalways. At its simplest, it is used as a simulation tool. It provides a concise, efficient way tosimulate multiple data sets under plausible evolutionary scenarios (that is, to simulatedata in the first sense that was defined in the introduction). Data that are simulated usingthe coalescent are also used to underpin methods for statistical analysis, such as thosewe discuss later. The main limitations of the coalescent are, for example, that it assumesrather simplistic models for population structure and selection, and can become highlycomputationally intensive when simulating long chromosomal regions24.
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