evolving all we are
2012年3月22日星期四
model Based CpG Islands for multiple species - R package
makeCGI
is
an
R
software
package
to
obtain
CGI
from
a
genome
.
It
fits
two
HMMs
on
GC
content
and
observed
to
expected
CpG
ratio
iteratively
and
obtain
posterior
probabilities
for
genomic
regions
being
CpG
islands
.
The
CpG
islands
are
then
defined
by
thresholding
the
posterior
probabilities
.
The software package can be downloaded from
here
. It depends on
BSgenome
and
Biostrings
BioConductor
packages
.
The
input
DNA
sequence
can
be
either
a
BSgenome
package
or
text
file
in
fa
format
.
Follow
below
steps
to
use
the
package
http://rafalab.jhsph.edu/CGI/index.html
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